2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Bcl-2 Family Antagonist

Bcl-2 Family Antagonist

Bcl-2 Family Isoform Comparison

Bcl-2 Family Antagonists (8):

Cat. No. Product Name Effect Purity
  • HY-13407
    Gossypol
    		Antagonist 99.67%
    Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-12908
    Bcl-xL antagonist 2
    		Antagonist 98.86%
    Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL).
  • HY-130261
    Mcl-1 antagonist 1
    		Antagonist
    Mcl-1 antagonist 1 is a Mcl-1 protein antagonist extracted from patent WO2019173181, compound 200.
  • HY-123020
    CYD-2-88
    		Antagonist
    CYD-2-88 (BDA-366 analog) is a BDA-366 (HY-101083) (Bcl2 BH4 antagonist) analog. CYD-2-88 (20 mg/kg, i.p.) inhibits tumor growth in NSCLC H460 xenografts mice.
  • HY-101083
    BDA-366
    		Antagonist
    BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells.
  • HY-123244
    YC137
    		Antagonist
    YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research.
  • HY-13407R
    Gossypol (Standard)
    		Antagonist
    Gossypol (Standard) is the analytical standard of Gossypol. This product is intended for research and analytical applications. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
  • HY-P0300
    Bak BH3
    		Antagonist
    Bak BH3 is derived from the BH3 domain of Bak, can antagonize the function of Bcl-xL in cells.